Reaction Details |
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Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
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Ligand | BDBM50110183 |
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Substrate/Competitor | n/a |
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Meas. Tech. | CDK Kinase Assays |
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IC50 | 2.00±n/a nM |
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Citation | Wang, Y; Wang, J; Ding, L Benzimidazole derivatives, preparation methods and uses thereof US Patent US11053238 Publication Date 7/6/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
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Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
Synonyms: | CDK4/Cyclin D3 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1806445 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 4 |
Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
Type: | Enzyme Subunit |
Mol. Mass.: | 33731.96 |
Organism: | Homo sapiens (Human) |
Description: | P11802 |
Residue: | 303 |
Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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Component 2 |
Name: | G1/S-specific cyclin-D3 |
Synonyms: | CCND3 | CCND3_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 32521.90 |
Organism: | Homo sapiens (Human) |
Description: | P30281 |
Residue: | 292 |
Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
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BDBM50110183 |
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n/a |
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Name | BDBM50110183 |
Synonyms: | Abemaciclib | LY-2835219 | US10626107, Example LY2835219 | US10662186, Compound LY2835219 | US10696678, Example LY2835219 | US10988476, Compound LY2835219 | US11053238, LY2835219 | US11091476, Example LY2835219 | US11351170, Example Abemaciclib |
Type | Small organic molecule |
Emp. Form. | C27H32F2N8 |
Mol. Mass. | 506.5934 |
SMILES | CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 |
Structure |
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