| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B |
|---|
| Ligand | BDBM50110183 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | CDK Kinase Assays |
|---|
| IC50 | 308±0.0 nM |
|---|
| Citation |  Wang, Y; Wang, J; Ding, L Benzimidazole derivatives, preparation methods and uses thereof US Patent US11053238 Publication Date 7/6/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B |
|---|
| Name: | Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B |
|---|
| Synonyms: | CDK1/Cyclin B | Cyclin-Dependent Kinase 1 (CDK1) | p34cdc2/Cyclin B |
|---|
| Type: | Protein Complex |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | p34cdc2/cyclin B was purified from M-phase starfish oocytes by affinity chromatography. |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 1 |
|---|
| Synonyms: | CDK1_ORYLA | Cell division control protein 2 (cdc2) | P34 protein kinase | cdc2 | cdk1 |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 34693.35 |
|---|
| Organism: | Marthasterias glacialis (starfish) |
|---|
| Description: | Q9DGD3 {empty hard to find) |
|---|
| Residue: | 303 |
|---|
| Sequence: | MEDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKH
PNVVRLLDVLMQESRLYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCH
RRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGSPR
YSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVWPDVESLPDYKNT
FPKWKEGSLSSMVKNLDKNGLDLLAKMLIYNPPKRISAREAMTHPYFDDLDKSTLPAACI
NGV
|
|
|
|---|
| Component 2 |
| Name: | G2/mitotic-specific cyclin-B |
|---|
| Synonyms: | CCNB_MARGL | Cyclin B | G2/mitotic-specific cyclin-B1 |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 43790.28 |
|---|
| Organism: | Marthasterias glacialis (starfish) |
|---|
| Description: | n/a |
|---|
| Residue: | 388 |
|---|
| Sequence: | MLNGENVDSRIMGKVATRASSKGVKSTLGTRGALENISNVARNNLQAGAKKELVKAKRGM
TKSKATSSLQSVMGLNVEPMEKAKPQSPEPMDMSEINSALEAFSQNLLEGVEDIDKNDFD
NPQLCSEFVNDIYQYMRKLEREFKVRTDYMTIQEITERMRSILIDWLVQVHLRFHLLQET
LFLTIQILDRYLEVQPVSKNKLQLVGVTSMLIAAKYEEMYPPEIGDFVYITDNAYTKAQI
RSMECNILRRLDFSLGKPLCIHFLRRNSKAGGVDGQKHTMAKYLMELTLPEYAFVPYDPS
EIAAAALCLSSKILEPDMEWGTTLVHYSAYSEDHLMPIVQKMALVLKNAPTAKFQAVRKK
YSSAKFMNVSTISALTSSTVMDLADQMC
|
|
|
|---|
| BDBM50110183 |
|---|
| n/a |
|---|
| Name | BDBM50110183 |
|---|
| Synonyms: | Abemaciclib | LY-2835219 | US10626107, Example LY2835219 | US10662186, Compound LY2835219 | US10696678, Example LY2835219 | US10988476, Compound LY2835219 | US11053238, LY2835219 | US11091476, Example LY2835219 | US11351170, Example Abemaciclib |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H32F2N8 |
|---|
| Mol. Mass. | 506.5934 |
|---|
| SMILES | CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
