Ki Summary

Reaction Details

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Target

Toll-like receptor 8

Ligand

BDBM428023

Substrate/Competitor

n/a

Meas. Tech.

TLR7/8/9 Inhibition Reporter Assays

IC50

0.300±n/a nM

Citation

Dyckman, AJ; Dodd, DS; Mussari, CP; Sherwood, TC; Whiteley, BK; Gilmore, JL; Kumar, SR; Pasunoori, L; Srinivas, PV; Duraisamy, SK; Hegde, S; Anumula, RK 4-azaindole compounds US Patent US11053244 Publication Date 7/6/2021

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 8

Name:

Toll-like receptor 8

Synonyms:

CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8

Type:

Enzyme

Mol. Mass.:

119828.77

Organism:

Homo sapiens (Human)

Description:

Q9NR97

Residue:

1041

Sequence:

MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY

BDBM428023

n/a

Name

BDBM428023

Synonyms:

US10544143, Example 457 | US10544143, Example 458 | US10730877, Example 458 | US11053244, Example 458

Type

Small organic molecule

Emp. Form.

C29H37N7O2S

Mol. Mass.

547.715

SMILES

CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)N(CCS(C)(=O)=O)CC#N)-c1cn2ncnc2c(C)c1C |(2.45,1.69,;3.54,.6,;5.02,1,;3.14,-.89,;4.04,-2.13,;3.14,-3.38,;1.67,-2.9,;.34,-3.67,;-.99,-2.9,;-.99,-1.36,;.34,-.59,;1.67,-1.36,;-2.33,-.59,;-2.33,.95,;-3.66,1.72,;-5,.95,;-5,-.59,;-3.66,-1.36,;-6.33,1.72,;-7.66,.95,;-7.66,-.59,;-9,-1.36,;-9.77,-.03,;-8.23,-2.69,;-10.33,-2.13,;-6.33,3.26,;-5,4.03,;-3.66,4.8,;5.58,-2.13,;6.35,-.8,;7.89,-.8,;8.92,.35,;10.33,-.28,;10.17,-1.81,;8.66,-2.13,;7.89,-3.47,;8.66,-4.8,;6.35,-3.47,;5.58,-4.8,)|

Structure