Reaction Details |
| Report a problem with these data |
Target | Estrogen receptor [298-554] |
---|
Ligand | BDBM521203 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Biochemical Antagonist Activity on Wild Type (WT) and Mutants |
---|
IC50 | 2.00±n/a nM |
---|
Citation | Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof US Patent US11149031 Publication Date 10/19/2021 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Estrogen receptor [298-554] |
---|
Name: | Estrogen receptor [298-554] |
Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen Receptor alpha (aa 298-554) | NR3A1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 29227.65 |
Organism: | Homo sapiens (Human) |
Description: | P03372[298-554] |
Residue: | 256 |
Sequence: | KRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCV
EGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRV
LDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYD
LLLEMLDAHRLHAPTS
|
|
|
BDBM521203 |
---|
n/a |
---|
Name | BDBM521203 |
Synonyms: | 3-(6-ethoxy-2- fluoro-3- pyridyl)-4-[4- [(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxyphenyl]- 2H- thiochromen-7- ol | US11149031, Example 27 |
Type | Small organic molecule |
Emp. Form. | C29H30F2N2O3S |
Mol. Mass. | 524.622 |
SMILES | CCOc1ccc(C2=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c3ccc(O)cc3SC2)c(F)n1 |r,c:7| |
Structure |
|