| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [695-1022,T790M,C797S,L858R] |
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| Ligand | BDBM525425 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical EGFR Inhibition Assays (5 mM ATP) |
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| IC50 | 1.50±n/a nM |
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| Citation |  Boese, D; Dahmann, G; Engelhardt, H; Petronczki, M; Scharn, D Benzimidazole compounds and derivatives as EGFR inhibitors US Patent US11174245 Publication Date 11/16/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [695-1022,T790M,C797S,L858R] |
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| Name: | Epidermal growth factor receptor [695-1022,T790M,C797S,L858R] |
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| Synonyms: | EGFR | EGFR (aa 695-1022, L858R, T790M, C797S) | EGFR_HUMAN | ERBB | ERBB1 | HER1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 37397.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[695-1022,T790M,C797S,L858R] |
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| Residue: | 328 |
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| Sequence: | SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPK
ANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYL
LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGG
KVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLP
QPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTD
SNFYRALMDEEDMDDVVDADEYLIPQQG
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| BDBM525425 |
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| n/a |
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| Name | BDBM525425 |
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| Synonyms: | US11174245, # I-008 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33N7O2 |
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| Mol. Mass. | 511.618 |
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| SMILES | CC(=O)N1CCC(CC1)c1ccc2n(C3CCCC3)\c(=N\C(=O)c3ccnc(c3)-c3cnn(C)c3)[nH]c2c1 |
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| Structure | 
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