Ki Summary

Reaction Details

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Target

Epidermal growth factor receptor [695-1022,T790M,C797S,L858R]

Ligand

BDBM525490

Substrate/Competitor

n/a

Meas. Tech.

Biochemical EGFR Inhibition Assays (5 mM ATP)

IC50

1.90±n/a nM

Citation

Boese, D; Dahmann, G; Engelhardt, H; Petronczki, M; Scharn, D Benzimidazole compounds and derivatives as EGFR inhibitors US Patent US11174245 Publication Date 11/16/2021

More Info.:

Get all data from this article, Assay Method

Epidermal growth factor receptor [695-1022,T790M,C797S,L858R]

Name:

Epidermal growth factor receptor [695-1022,T790M,C797S,L858R]

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

37397.86

Organism:

Homo sapiens (Human)

Description:

P00533[695-1022,T790M,C797S,L858R]

Residue:

328

Sequence:

SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPK
ANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYL
LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGG
KVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLP
QPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTD
SNFYRALMDEEDMDDVVDADEYLIPQQG

BDBM525490

n/a

Name

BDBM525490

Synonyms:

US11174245, # I-143

Type

Small organic molecule

Emp. Form.

C24H26N6O2

Mol. Mass.

430.5022

SMILES

Cc1cc(cc(n1)-c1cnn(C)c1)C(=O)\N=c1/[nH]c2ccccc2n1[C@@H]1CC[C@H](O)CC1 |r,wU:25.28,28.32,(4.98,5.6,;4.21,4.26,;2.67,4.26,;1.9,2.93,;2.67,1.6,;4.21,1.6,;4.98,2.93,;4.98,.26,;6.52,.26,;6.99,-1.2,;5.75,-2.11,;5.75,-3.65,;4.5,-1.2,;.36,2.93,;-.41,4.26,;-.41,1.6,;-1.95,1.6,;-2.86,2.84,;-4.32,2.37,;-5.66,3.14,;-6.99,2.37,;-6.99,.83,;-5.66,.06,;-4.32,.83,;-2.86,.35,;-2.46,-1.14,;-3.55,-2.22,;-3.15,-3.71,;-1.66,-4.11,;-1.27,-5.6,;-.57,-3.02,;-.97,-1.53,)|

Structure