Ki Summary

Reaction Details

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Target

Epidermal growth factor receptor [695-745,751-1022,T790M,C797S]

Ligand

BDBM525547

Substrate/Competitor

n/a

Meas. Tech.

Biochemical EGFR Inhibition Assays (5 mM ATP)

IC50

0.200±n/a nM

Citation

Boese, D; Dahmann, G; Engelhardt, H; Petronczki, M; Scharn, D Benzimidazole compounds and derivatives as EGFR inhibitors US Patent US11174245 Publication Date 11/16/2021

More Info.:

Get all data from this article, Assay Method

Epidermal growth factor receptor [695-745,751-1022,T790M,C797S]

Name:

Epidermal growth factor receptor [695-745,751-1022,T790M,C797S]

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

36756.18

Organism:

Homo sapiens (Human)

Description:

P00533[695-745,751-1022,T790M,C797S]

Residue:

323

Sequence:

SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEI
LDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCV
QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIK
WMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC
TIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYR
ALMDEEDMDDVVDADEYLIPQQG

BDBM525547

n/a

Name

BDBM525547

Synonyms:

US11174245, # I-225

Type

Small organic molecule

Emp. Form.

C30H37N7O2

Mol. Mass.

527.6605

SMILES

CN1CCC(CC1)c1ccc2[nH]\c(=N/C(=O)c3cc(C)nc(c3)-c3cnn(C)c3)n([C@@H]3CC[C@H](O)CC3)c2c1 |r,wU:30.32,33.36,(-9.66,-2.25,;-8.33,-1.48,;-8.33,.06,;-6.99,.83,;-5.66,.06,;-5.66,-1.48,;-6.99,-2.25,;-4.32,.83,;-4.32,2.37,;-2.99,3.14,;-1.66,2.37,;-.19,2.84,;.71,1.6,;2.25,1.6,;3.02,2.93,;2.25,4.26,;4.56,2.93,;5.33,4.26,;6.87,4.26,;7.64,5.6,;7.64,2.93,;6.87,1.6,;5.33,1.6,;7.64,.26,;9.18,.26,;9.66,-1.2,;8.41,-2.11,;8.41,-3.65,;7.17,-1.2,;-.19,.35,;.21,-1.14,;-.88,-2.22,;-.48,-3.71,;1,-4.11,;1.4,-5.6,;2.09,-3.02,;1.69,-1.53,;-1.66,.83,;-2.99,.06,)|

Structure