| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor XI |
|---|
| Ligand | BDBM303812 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Measurement of FXIa Inhibition |
|---|
| IC50 | 4.50±n/a nM |
|---|
| Citation |  Röhrig, S; Hillisch, A; Heitmeier, S; Schmidt, MV; Schlemmer, K; Tersteegen, A; Schäfer, M; Teller, H; Jimènez Nùnez, E Factor xia-inhibiting pyridobenzazepine and pyridobenzazocine derivatives US Patent US10138236 Publication Date 11/27/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor XI |
|---|
| Name: | Coagulation factor XI |
|---|
| Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 70130.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03951 |
|---|
| Residue: | 625 |
|---|
| Sequence: | MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
|
|
|
|---|
| BDBM303812 |
|---|
| n/a |
|---|
| Name | BDBM303812 |
|---|
| Synonyms: | 2-(11′-Chloro-2′,5′-dioxo-2′,5′,6′,8′-tetrahydro-3′H-spiro[cyclopropane-1,7′-pyrido[3,4-e][3]benzazocine]-3′-yl)-N-(2-methyl-2H-indazol-5-yl)-3-phenylpropanamide (Stereoisomer Mixture) | US10138236, Example 30 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H28ClN5O3 |
|---|
| Mol. Mass. | 578.06 |
|---|
| SMILES | Cn1cc2cc(NC(=O)C(Cc3ccccc3)n3cc4c(cc3=O)-c3cc(Cl)ccc3CC3(CC3)NC4=O)ccc2n1 |$;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;$| |
|---|
| Structure | 
|
|---|
Search and Browse
