| Reaction Details |
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 | Report a problem with these data |
| Target | Taste receptor type 1 member 1/3 |
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| Ligand | BDBM525923 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Activation of T1R1/T1R3 Receptor by Nucleotide Derivatives |
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| EC50 | 20000±9000 nM |
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| Citation |  McGrane, SJ; Taylor, AJ; Fine, RM; Klebansky, B; Gibbs, MR Methods for modulating taste receptors US Patent US11185100 Publication Date 11/30/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Taste receptor type 1 member 1/3 |
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| Name: | Taste receptor type 1 member 1/3 |
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| Synonyms: | Taste Receptor T1R1/T1R3 |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Taste receptor type 1 member 1 |
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| Synonyms: | GPR70 | T1R1 | TAS1R1 | TR1 | TS1R1_HUMAN | Taste receptor type 1 member 1 (T1R1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 93094.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q7RTX1 |
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| Residue: | 841 |
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| Sequence: | MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT
LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS
LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR
QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA
FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS
EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS
NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ
LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE
TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCG
KEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSA
GGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF
KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLEC
TETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTA
SVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRRCGS
T
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| Component 2 |
| Name: | Taste receptor type 1 member 3 |
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| Synonyms: | T1R3 | TAS1R3 | TR3 | TS1R3_HUMAN | Taste receptor type 1 member 3 (T1R3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 93393.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q7RTX0 |
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| Residue: | 852 |
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| Sequence: | MLGPAVLGLSLWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSP
VCTRFSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKA
GSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETF
PSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHE
GLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVAS
EAWLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYVKTHLALATDPAFCSALGEREQG
LEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDP
VKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRT
ERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDIACTF
CGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQ
ASGGPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAEIFV
ESELPLSWADRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALV
HCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGCYNRARGLTFAMLAYFITWVSFVP
LLANVQVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPEFFLGGGPGDAQGQ
NDGNTGNQGKHE
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| BDBM525923 |
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| n/a |
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| Name | BDBM525923 |
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| Synonyms: | US11185100, TABLE 6.1 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H15N5O9P2 |
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| Mol. Mass. | 411.2017 |
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| SMILES | Nc1ncnc2n(cnc12)[C@H]1C[C@@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1 |r| |
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| Structure | 
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