Ki Summary

Reaction Details

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Target

Diacylglycerol O-acyltransferase 2

Ligand

BDBM530641

Substrate/Competitor

n/a

Meas. Tech.

DGAT2 enzymatic activity assay

IC50

2.40±n/a nM

Citation

Yeon-Hee, L; R., AE; Jianming, B; Chen, C; P., RJ; Helen, SE PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS WIPOWO2022076495 Publication Date 4/14/2022

More Info.:

Get all data from this article, Assay Method

Diacylglycerol O-acyltransferase 2

Name:

Diacylglycerol O-acyltransferase 2

Synonyms:

Type:

Multi-pass membrane protein

Mol. Mass.:

43848.90

Organism:

Homo sapiens (Human)

Description:

Q96PD7

Residue:

388

Sequence:

MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN

BDBM530641

n/a

Name

BDBM530641

Synonyms:

WO2022076495, EXAMPLE 75b

Type

Small organic molecule

Emp. Form.

C27H31F4N3O6S

Mol. Mass.

601.61

SMILES

C[C@@H](n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OCC(F)F)ccc2F)c1=O)C(C)(C)O |r,wD:1.0,(.14,1.73,;1.65,1.41,;2.13,-.06,;3.59,-.53,;4.92,.24,;6.26,-.53,;7.59,.24,;7.59,1.78,;8.93,-.53,;10.26,.24,;10.79,-1.21,;9.27,1.42,;9.8,2.86,;11.31,3.13,;10.79,4.58,;12.65,3.9,;12.3,1.95,;11.78,.5,;6.26,-2.07,;7.59,-2.84,;4.92,-2.84,;3.59,-2.07,;2.13,-2.55,;1.65,-4.01,;.14,-4.33,;-.33,-5.8,;-1.84,-6.12,;-2.87,-4.97,;-4.38,-5.29,;-5.41,-4.15,;-4.85,-6.76,;.7,-6.94,;2.2,-6.62,;2.68,-5.16,;4.19,-4.84,;1.22,-1.3,;-.32,-1.3,;2.68,2.55,;4.19,2.23,;3.16,1.09,;2.2,4.02,)|

Structure