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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 2 | ||
| Ligand | BDBM530684 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DGAT2 enzymatic activity assay | ||
| IC50 | 4.10±n/a nM | ||
| Citation |  Yeon-Hee, L; R., AE; Jianming, B; Chen, C; P., RJ; Helen, SE PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS WIPOWO2022076495 Publication Date 4/14/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 2 | |||
| Name: | Diacylglycerol O-acyltransferase 2 | ||
| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 43848.90 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96PD7 | ||
| Residue: | 388 | ||
| Sequence: |
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| BDBM530684 | |||
| n/a | |||
| Name | BDBM530684 | ||
| Synonyms: | WO2022076495, EXAMPLE 115 | l-(2-(2,2-difluoroethoxy)-5-fluoropyridin-4-yl)-6-fluoro-3-isopropyl-N-(4-methyl-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2-oxo-2,3-dihydro--be1Hnzo[d]imidazole-5-carboxamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24F4N4O5S | ||
| Mol. Mass. | 544.519 | ||
| SMILES | CC(C)n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OC(F)F)ncc2F)c1=O |(.14,1.73,;1.65,1.41,;2.68,2.55,;2.13,-.06,;3.59,-.53,;4.92,.24,;6.26,-.53,;7.59,.24,;7.59,1.78,;8.93,-.53,;10.26,.24,;10.79,-1.21,;9.27,1.42,;9.8,2.86,;11.31,3.13,;10.79,4.58,;12.65,3.9,;12.3,1.95,;11.78,.5,;6.26,-2.07,;7.59,-2.84,;4.92,-2.84,;3.59,-2.07,;2.13,-2.55,;1.65,-4.01,;.14,-4.33,;-.33,-5.8,;-1.84,-6.12,;-2.87,-4.97,;-4.38,-5.29,;-2.39,-3.51,;.7,-6.94,;2.2,-6.62,;2.68,-5.16,;4.19,-4.84,;1.22,-1.3,;-.32,-1.3,)| | ||
| Structure | 
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