| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein kinase TTK |
|---|
| Ligand | BDBM258443 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TTK Enzyme Assay |
|---|
| IC50 | 0.600±n/a nM |
|---|
| Citation |  De Roos, J; Uitdehaag, JC; De Man, AP; Buijsman, RC; Zaman, GJ Prognostic biomarkers for TTK inhibitor chemotherapy US Patent US11208696 Publication Date 12/28/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein kinase TTK |
|---|
| Name: | Dual specificity protein kinase TTK |
|---|
| Synonyms: | Dual specificity protein kinase (TTK) | Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | Monopolar Spindle 1 (MPS1) | Monopolar Spindle 1 (Mps-1) | Monopolar Spindle 1 Kinase (MPS1) | Phosphotyrosine picked threonine-protein kinase (MPS1) | TTK | TTK_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 97086.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P33981 |
|---|
| Residue: | 857 |
|---|
| Sequence: | MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
SHNSSSSKTFEKKRGKK
|
|
|
|---|
| BDBM258443 |
|---|
| n/a |
|---|
| Name | BDBM258443 |
|---|
| Synonyms: | US11208696, Example 6 | US9512130, 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H28FN5O4 |
|---|
| Mol. Mass. | 517.5514 |
|---|
| SMILES | COc1ccc(Oc2cc(NCC3COC3)c3ncc(-c4ccc(C(=O)NC5CC5)c(C)c4)n3n2)cc1F |
|---|
| Structure | 
|
|---|
Search and Browse
