| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-3 |
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| Ligand | BDBM377205 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Pim Enzyme Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Xue, C; Li, Y; Feng, H; Pan, J; Wang, A; Zhang, K; Yao, W; Zhang, F; Zhuo, J Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors US Patent US11229631 Publication Date 1/25/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-3 |
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| Name: | Serine/threonine-protein kinase pim-3 |
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| Synonyms: | PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3) |
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| Type: | Protein |
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| Mol. Mass.: | 35888.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86V86 |
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| Residue: | 326 |
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| Sequence: | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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| BDBM377205 |
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| n/a |
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| Name | BDBM377205 |
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| Synonyms: | 5-Amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide | US10265307, Example 49 | US10517858, Example 49 (Diastereoisomer 1) | US10828290, Example 49 (Diastereoisomer 1) | US11229631, Example 49 Diastereoisomer 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26F2N6O3S |
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| Mol. Mass. | 516.563 |
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| SMILES | C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F |r| |
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| Structure | 
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