Reaction Details |
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Target | B-cell lymphoma 6 protein [1-129]/Nuclear receptor corepressor 2 [1414-1429] |
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Ligand | BDBM536438 |
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Substrate/Competitor | n/a |
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Meas. Tech. | BCL6-BTB-SMRT Peptide Inhibition Fluorescence Polarization (FP) Screen |
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Kd | 49.6±n/a nM |
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Citation | Al-awar, R; Isaac, M; Chau, AM; Mamai, A; Watson, I; Poda, G; Subramanian, P; Wilson, B; Uehling, D Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof US Patent US11242351 Publication Date 2/8/2022 |
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More Info.: | Get all data from this article, Assay Method |
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B-cell lymphoma 6 protein [1-129]/Nuclear receptor corepressor 2 [1414-1429] |
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Name: | B-cell lymphoma 6 protein [1-129]/Nuclear receptor corepressor 2 [1414-1429] |
Synonyms: | BCL6-BTB domain and SMRT/NCOR2 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | B-cell lymphoma 6 protein [1-129] |
Synonyms: | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 (aa 1-129) | LAZ3 | ZBTB27 | ZNF51 |
Type: | PROTEIN |
Mol. Mass.: | 14696.53 |
Organism: | Homo sapiens |
Description: | P41182[1-129] |
Residue: | 129 |
Sequence: | MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSI
FTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDT
CRKFIKASE
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Component 2 |
Name: | Nuclear receptor corepressor 2 [1414-1429] |
Synonyms: | CTG26 | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2 (aa 1414-1429) |
Type: | Enzyme |
Mol. Mass.: | 1720.48 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y618[1414-1429] |
Residue: | 16 |
Sequence: | |
BDBM536438 |
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n/a |
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Name | BDBM536438 |
Synonyms: | (S)-5-(1-(2-((5-chloro- 2-(2,4-dimethyl- piperazin-1-yl)pyridin- 4-yl)amino)-2-oxoethyl)- 4-oxo-4,6,7,8-tetrahydro- 1H-dipyrrolo[1,2-a:2',3'- d]pyrimidin-3-yl)-4- fluoro-2-hydroxy-3- methoxybenzamide | US11242351, Compound I-17 |
Type | Small organic molecule |
Emp. Form. | C30H32ClFN8O5 |
Mol. Mass. | 639.077 |
SMILES | COc1c(O)c(cc(-c2cn(CC(=O)Nc3cc(ncc3Cl)N3CCN(C)C[C@@H]3C)c3nc4CCCn4c(=O)c23)c1F)C(N)=O |r| |
Structure |
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