| Reaction Details |
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 | Report a problem with these data |
| Target | B-cell lymphoma 6 protein [1-129]/Nuclear receptor corepressor 2 [1414-1429] |
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| Ligand | BDBM536473 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | BCL6-BTB-SMRT Peptide Inhibition Fluorescence Polarization (FP) Screen |
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| Kd | 76.5±n/a nM |
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| Citation |  Al-awar, R; Isaac, M; Chau, AM; Mamai, A; Watson, I; Poda, G; Subramanian, P; Wilson, B; Uehling, D Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof US Patent US11242351 Publication Date 2/8/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| B-cell lymphoma 6 protein [1-129]/Nuclear receptor corepressor 2 [1414-1429] |
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| Name: | B-cell lymphoma 6 protein [1-129]/Nuclear receptor corepressor 2 [1414-1429] |
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| Synonyms: | BCL6-BTB domain and SMRT/NCOR2 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | B-cell lymphoma 6 protein [1-129] |
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| Synonyms: | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 (aa 1-129) | LAZ3 | ZBTB27 | ZNF51 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 14696.53 |
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| Organism: | Homo sapiens |
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| Description: | P41182[1-129] |
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| Residue: | 129 |
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| Sequence: | MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSI
FTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDT
CRKFIKASE
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| Component 2 |
| Name: | Nuclear receptor corepressor 2 [1414-1429] |
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| Synonyms: | CTG26 | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2 (aa 1414-1429) |
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| Type: | Enzyme |
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| Mol. Mass.: | 1720.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y618[1414-1429] |
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| Residue: | 16 |
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| Sequence: | |
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| BDBM536473 |
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| n/a |
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| Name | BDBM536473 |
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| Synonyms: | (S)-5-(1-(2-((3-chloro- 6-(4-ethyl-2-methyl- piperazin-1-yl)-2- fluoropyridin-4-yl) amino)-2-oxoethyl)- 4-oxo-4,6,7,8,9,10- hexahydro-1H-pyrrolo [2',3':4,5]pyrimido [1,2-a]azepin-3-yl)- 3,4-difluoro-2-hydroxy- benzamide | US11242351, Compound I-52 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H34ClF3N8O4 |
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| Mol. Mass. | 687.112 |
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| SMILES | CCN1CCN([C@@H](C)C1)c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(F)c3F)c3c2nc2CCCCCn2c3=O)c(Cl)c(F)n1 |r| |
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| Structure | 
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