| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent protein kinase |
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| Ligand | BDBM340946 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Luminescent Kinase Assay |
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| IC50 | 4.90±n/a nM |
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| Citation |  Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent US11247972 Publication Date 2/15/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-dependent protein kinase |
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| Name: | cGMP-dependent protein kinase |
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| Synonyms: | KGP_TOXGO | PKG | TgPKG |
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| Type: | Protein |
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| Mol. Mass.: | 111249.85 |
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| Organism: | n/a |
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| Description: | Q8MMZ7 |
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| Residue: | 994 |
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| Sequence: | MGACISKNSSARVSRSSALSASKQTVAASAPPGAAGDETSATGAAEEASRNSLARVDGTR
ASAAELERAPDGVCPDREEPGTANAEQGGVTEKKDTRETLAGMNSPKTLEAEAQEDDPKR
EAPNQDVPSEAPEGPKEKPGGDRKPAQKAILKQDDSHTEEEKLNAHLAYREKTPADFALI
QDSLKANLVCSSLNEGEIDALAVAMQFFTFKKGDVVTKQGEPGSYFFIIHSGTFDVLVND
KRVNAMDKGKAFGEIALIHNTERSATVVASSTEGALWGVQRHTFRETLKQLSSRNFAENR
QFLASVKFFEMLTEAQKNVITNALVVENFKPGQPIVKEGDAGDVLYILKSGKAKVSIGGR
EIRMLRKGDYFGERALLYKEPRSATITAEEFTVCVSIGRELLDRVLGNLQHVLFRNIMVE
ALQQSKVYELFQGDQLSKLIEAAVVKDYGADYVILDKENKTKGIRFFFVLEGELSVYAYT
QNPATKEEERKLAATLKRGQAFGEEYVLNPTRPFNHYVKSVGPCKLALFTSSVLTATLGG
EDIDETLDFNNKRAIIRKMYIFRYLSDHQMTMLIKAFKTVRYMSGEYIIKEGERGTRFFI
IKAGEVAILKNNKRLRTLGRHDYFGERALLYDKPRTASVCANSAGVDLWVVDKSVFNEII
KGPMLAHLEERIRMQDTKVEFQDLQVVRVVGRGTFGTVKLVRHVPTDIRYALKCVSRRSV
IALSQQQHIRLEREIMAENDHPFIIRLVRTFRDKEFLYFLTELVTGGELYDAIRKLGLLA
RSQAQFYLASIVLAIEYLHERNIAYRDLKPENILLDSQGYVKLIDFGCAKKMQGRAYTLV
GTPHYMAPEVILGKGYTLTADTWAFGVCLYEFMCGPLPFGNDAEDQLEIFRDILTGKLVF
PHYVTDQDAINLMKRLLCRLPEVRIGCSINGYKDIKEHAFFGDFDWDKLAGRGLPPPLAP
KGETYAEDTEQSSFELDEDDTIVLEDEYDWDKDF
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|
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| BDBM340946 |
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| n/a |
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| Name | BDBM340946 |
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| Synonyms: | 3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[1,5-a]pyrazin-8-amine | US10544104, Compound 71 | US11247972, Compound 71 | US9765037, Compound 71 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N4O |
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| Mol. Mass. | 346.4256 |
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| SMILES | COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C |
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| Structure | 
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