Reaction Details |
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Target | Macrophage colony-stimulating factor 1 receptor |
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Ligand | BDBM542831 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Studies |
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IC50 | 8.00±n/a nM |
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Citation | Kane, Jr., JL; Barberis, C; Czekaj, M; Erdman, P; Giese, B; Kothe, M; Le, T; Liu, J; Ma, L; Metz, M; Patel, V; Scholte, A; Shum, PW; Wei, L Colony stimulating factor-1 receptor (CSF-1R) inhibitors US Patent US11274108 Publication Date 3/15/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Macrophage colony-stimulating factor 1 receptor |
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Name: | Macrophage colony-stimulating factor 1 receptor |
Synonyms: | CSF1R | CSF1R_HUMAN | FMS | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms | cFMS |
Type: | Protein |
Mol. Mass.: | 107979.48 |
Organism: | Homo sapiens (Human) |
Description: | P07333 |
Residue: | 972 |
Sequence: | MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL
YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED
QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL
MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN
NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY
LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY
RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA
ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN
QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY
KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT
AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL
VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV
DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA
ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS
YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR
PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA
QPLLQPNNYQFC
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BDBM542831 |
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n/a |
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Name | BDBM542831 |
Synonyms: | 3-((2-(6-cyclopropylpyridin-3-yl)-8-methoxy-2,3- dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-6-((1- methylazetidin-3-yl)oxy)-3H-imidazo[4,5-b]pyridine | 3-((2-(6-cyclopropylpyridin-3-yl)-8-methoxy-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-6-((1-methylazetidin-3-yl)oxy)-3H-imidazo[4,5-b]pyridine | US11274108, Example 1-116 |
Type | Small organic molecule |
Emp. Form. | C28H29N5O4 |
Mol. Mass. | 499.561 |
SMILES | COc1cc(Cn2cnc3cc(OC4CN(C)C4)cnc23)cc2OCC(Oc12)c1ccc(nc1)C1CC1 |
Structure |
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