Reaction Details | |||
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Target | Proto-oncogene tyrosine-protein kinase receptor Ret | ||
Ligand | BDBM434996 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biochemical Activity Assay | ||
IC50 | <10±n/a nM | ||
Citation | Brubaker, JD; Kim, JL; Wilson, KJ; Wilson, D; DiPietro, LV Inhibitors of RET US Patent US11279688 Publication Date 3/22/2022 | ||
More Info.: | Get all data from this article, Assay Method | ||
Proto-oncogene tyrosine-protein kinase receptor Ret | |||
Name: | Proto-oncogene tyrosine-protein kinase receptor Ret | ||
Synonyms: | CDHF12 | CDHR16 | Cadherin family member 12 | PTC | Proto-oncogene c-Ret | RET | RET51 | RET_HUMAN | Tyrosine-protein kinase Ret (RET) | ||
Type: | Protein | ||
Mol. Mass.: | 124318.29 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P07949 | ||
Residue: | 1114 | ||
Sequence: |
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BDBM434996 | |||
n/a | |||
Name | BDBM434996 | ||
Synonyms: | US10584114, Compound 109 | US11279688, Compound 109 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H31FN8O | ||
Mol. Mass. | 502.5864 | ||
SMILES | C[C@H](NC(=O)[C@H]1CC[C@@H](CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,wU:8.11,1.0,wD:5.4,(4,4.24,;4,2.7,;2.67,1.93,;1.33,2.7,;1.33,4.24,;,1.93,;-1.33,2.69,;-2.67,1.93,;-2.67,.38,;-1.33,-.38,;,.38,;-4,-.39,;-4,-1.93,;-5.33,-2.7,;-5.33,-4.24,;-6.67,-1.93,;-6.67,-.39,;-8,.38,;-9.34,-.39,;-10.74,.24,;-11.77,-.9,;-13.3,-.74,;-11,-2.24,;-9.5,-1.92,;-5.33,.38,;5.33,1.93,;5.33,.39,;6.67,-.38,;8,.39,;8,1.93,;6.67,2.7,;9.34,-.38,;10.74,.24,;11.77,-.9,;13.3,-.74,;11,-2.24,;9.5,-1.92,)| | ||
Structure |