Reaction Details | |||
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Target | Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] | ||
Ligand | BDBM435017 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | RET V804L Gatekeeper Mutant Assay | ||
IC50 | <10±n/a nM | ||
Citation | Brubaker, JD; Kim, JL; Wilson, KJ; Wilson, D; DiPietro, LV Inhibitors of RET US Patent US11279688 Publication Date 3/22/2022 | ||
More Info.: | Get all data from this article, Assay Method | ||
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] | |||
Name: | Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] | ||
Synonyms: | CDHF12 | CDHR16 | PTC | RET | RET kinase (V804L) | RET kinase mutant (V804L) | RET51 | RET_HUMAN | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 124332.32 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P07949[V804L] | ||
Residue: | 1114 | ||
Sequence: |
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BDBM435017 | |||
n/a | |||
Name | BDBM435017 | ||
Synonyms: | US10584114, Compound 142 | US11279688, Compound 142 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H32F2N8O2 | ||
Mol. Mass. | 550.6029 | ||
SMILES | CO[C@]1(CC[C@](F)(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:2.25,26.29,5.5,wD:2.1,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-4.07,-.59,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| | ||
Structure |