| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [1-18,20-1210,C797S] |
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| Ligand | BDBM112499 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | pEGFR assay |
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| IC50 | 1.60±n/a nM |
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| Citation |  Harald, E; Mark, P; Juergen, R; Ulrich, R; Heinz, S; Dirk, S; Tobias, W SUBSTITUTED 1H-PYRAZOLO[4,3-C]PYRIDINES AND DERIVATIVES AS EGFR INHIBITORS WIPOWO2022090481 Publication Date 5/5/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [1-18,20-1210,C797S] |
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| Name: | Epidermal growth factor receptor [1-18,20-1210,C797S] |
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| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR)(del19/C797S) | HER1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 134160.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[1-18,20-1210,C797S] |
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| Residue: | 1209 |
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| Sequence: | MRPSGTAGAALLALLAALPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVV
LGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAV
LSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQ
NHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCT
GPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVV
TDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKN
CTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFE
NLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLF
GTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNL
LEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMG
ENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVA
LGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSG
AFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGIC
LTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAAR
NVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYG
VTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKF
RELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQ
GFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDS
IDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNT
VQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVA
PQSSEFIGA
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| BDBM112499 |
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| n/a |
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| Name | BDBM112499 |
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| Synonyms: | DACOMITINIB | US8623883, No. 2 | WO2022090481, Example dacomitinib |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25ClFN5O2 |
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| Mol. Mass. | 469.939 |
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| SMILES | COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1 |
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| Structure | 
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