Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase kinase kinase kinase 1

Ligand

BDBM548848

Substrate/Competitor

n/a

Meas. Tech.

HPK1-SLP76 TR-FRET ASSAY

IC50

0.05±n/a nM

Citation

A., CD; L., CJ; Anthony, D; Xavier, F; H., FP; Shuhei, K; Bing, L; Jongwon, L; Ping, L; L., MJ; G., NA; Alexander, P; A., VB; C., YE 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 WIPOWO2022098806 Publication Date 5/12/2022

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase kinase kinase kinase 1

Name:

Mitogen-activated protein kinase kinase kinase kinase 1

Synonyms:

HPK1 | M4K1_HUMAN | MAP4K1

Type:

PROTEIN

Mol. Mass.:

91316.07

Organism:

Homo sapiens (Human)

Description:

ChEMBL_586597

Residue:

833

Sequence:

MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL

BDBM548848

n/a

Name

BDBM548848

Synonyms:

WO2022098806, Compound 2-109

Type

Small organic molecule

Emp. Form.

C29H27FN8O

Mol. Mass.

522.5761

SMILES

CN1Cc2cc(Nc3ncc4c(N)c(F)c(-c5cnc6OCCNc6c5C)c(C#N)c4n3)ccc2C2(CC2)C1 |(-1,-6.56,;-2.33,-5.79,;-2.33,-4.25,;-3.66,-3.48,;-3.66,-1.94,;-5,-1.17,;-5,.37,;-3.66,1.14,;-3.66,2.68,;-2.33,3.45,;-1,2.68,;.33,3.45,;.33,4.99,;1.67,2.68,;3,3.45,;1.67,1.14,;3,.37,;4.33,1.14,;5.67,.37,;5.67,-1.17,;7,-1.94,;7,-3.48,;5.67,-4.25,;4.34,-3.48,;4.33,-1.94,;3,-1.17,;1.67,-1.94,;.33,.37,;.33,-1.17,;.33,-2.71,;-1,1.14,;-2.33,.37,;-6.33,-1.94,;-6.33,-3.47,;-5,-4.25,;-5,-5.79,;-6.5,-6.11,;-5.47,-7.25,;-3.66,-6.56,)|

Structure