| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 1 |
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| Ligand | BDBM552940 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogeneous Time Resolved Fluorescence (HTRF) Assay |
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| IC50 | <10±n/a nM |
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| Citation |  Pinchman, JR; Huang, PQ; Bunker, KD; Sit, RK; Samatar, AA Benzamide compounds US Patent US11318134 Publication Date 5/3/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 1 |
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| Name: | Bcl-2-like protein 1 |
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| Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
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| Type: | Mitochondrion membrane; Single-pass membrane protein |
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| Mol. Mass.: | 26039.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM552940 |
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| n/a |
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| Name | BDBM552940 |
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| Synonyms: | (R)-4-(4-((2-(3-(difluoromethyl)bicyclo[1.1.1]pentan-1-yl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((4-((4-((2-hydroxyethyl)(methyl)amino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide | US11318134, Example 60 |
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| Type | Small organic molecule |
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| Emp. Form. | C46H58F5N5O6S3 |
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| Mol. Mass. | 968.17 |
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| SMILES | CN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(CC2=C(CC(C)(C)CC2)C23CC(C2)(C3)C(F)F)CC1 |t:50| |
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| Structure | 
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