| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lys-gingipain |
|---|
| Ligand | BDBM453323 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Activity Assay |
|---|
| IC50 | <0.050±n/a nM |
|---|
| Citation |  Konradi, AW; Galemmo, Jr., RA; Dominy, SS; Lynch, CC; Holsinger, LJ Ketone inhibitors of lysine gingipain US Patent US11325884 Publication Date 5/10/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lys-gingipain |
|---|
| Name: | Lys-gingipain |
|---|
| Synonyms: | KGP_PORG3 | Lysine-specific cysteine proteinase Kgp | kgp |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 187217.55 |
|---|
| Organism: | Porphyromonas gingivalis |
|---|
| Description: | B2RLK2 |
|---|
| Residue: | 1723 |
|---|
| Sequence: | MRKLLLLIAASLLGVGLYAQSAKIKLDAPTTRTTCTNNSFKQFDASFSFNEVELTKVETK
GGTFASVSIPGAFPTGEVGSPEVPAVRKLIAVPVGATPVVRVKSFTEQVYSLNQYGSEKL
MPHQPSMSKSDDPEKVPFVYNAAAYARKGFVGQELTQVEMLGTMRGVRIAALTINPVQYD
VVANQLKVRNNIEIEVSFQGADEVATQRLYDASFSPYFETAYKQLFNRDVYTDHGDLYNT
PVRMLVVAGAKFKEALKPWLTWKAQKGFYLDVHYTDEAEVGTTNASIKAFIHKKYNDGLA
ASAAPVFLALVGDTDVISGEKGKKTKKVTDLYYSAVDGDYFPEMYTFRMSASSPEELTNI
IDKVLMYEKATMPDKSYLEKALLIAGADSYWNPKIGQQTIKYAVQYYYNQDHGYTDVYSY
PKAPYTGCYSHLNTGVGFANYTAHGSETSWADPSLTATQVKALTNKDKYFLAIGNCCVTA
QFDYPQPCFGEVMTRVKEKGAYAYIGSSPNSYWGEDYYWSVGANAVFGVQPTFEGTSMGS
YDATFLEDSYNTVNSIMWAGNLAATHAGNIGNITHIGAHYYWEAYHVLGDGSVMPYRAMP
KTNTYTLPASLPQNQASYSIQASAGSYVAISKDGVLYGTGVANASGVATVNMTKQITENG
NYDVVITRSNYLPVIKQIQAGEPSPYQPVSNLTATTQGQKVTLKWDAPSAKKAEASREVK
RIGDGLFVTIEPANDVRANEAKVVLAADNVWGDNTGYQFLLDADHNTFGSVIPATGPLFT
GTASSNLYSANFEYLIPANADPVVTTQNIIVTGQGEVVIPGGVYDYCITNPEPASGKMWI
AGDGGNQPARYDDFTFEAGKKYTFTMRRAGMGDGTDMEVEDDSPASYTYTVYRDGTKIQE
GLTATTFEEDGVAAGNHEYCVEVKYTAGVSPKVCKDVTVEGSNEFAPVQNLTGSAVGQKV
TLKWDAPNGTPNPNPNPNPGTTTLSESFENGIPASWKTIDADGDGHGWKPGNAPGIAGYN
SNGCVYSESFGLGGIGVLTPDNYLITPALDLPNGGKLTFWVCAQDANYASEHYAVYASST
GNDASNFTNALLEETITAKGVRSPEAIRGRIQGTWRQKTVDLPAGTKYVAFRHFQSTDMF
YIDLDEVEIKANGKRADFTETFESSTHGEAPAEWTTIDADGDGQDWLCLSSGQLDWLTAH
GGTNVVASFSWNGMALNPDNYLISKDVTGATKVKYYYAVNDGFPGDHYAVMISKTGTNAG
DFTVVFEETPNGINKGGARFGLSTEANGAKPQSVWIERTVDLPAGTKYVAFRHYNCSDLN
YILLDDIQFTMGGSPTPTDYTYTVYRDGTKIKEGLTETTFEEDGVATGNHEYCVEVKYTA
GVSPKVCVNVTINPTQFNPVKNLKAQPDGGDVVLKWEAPSGKRGELLNEDFEGDAIPTGW
TALDADGDGNNWDITLNEFTRGERHVLSPLRASNVAISYSSLLQGQEYLPLTPNNFLITP
KVEGAKKITYKVGSPGLPQWSHDHYALCISKSGTAAADFEVIFEETMTYTQGGANLTREK
DLPAGTKYVAFRHYNCTDVLGIMIDDVVITGEGEGPSYTYTVYRDGTKIQEGLTETTYRD
AGMSAQSHEYCVEVKYAAGVSPKVCVDYIPDGVADVTAQKPYTLTVVGKTITVTCQGEAM
IYDMNGRRLAAGRNTVVYTAQGGYYAVMVVVDGKSYVEKLAIK
|
|
|
|---|
| BDBM453323 |
|---|
| n/a |
|---|
| Name | BDBM453323 |
|---|
| Synonyms: | BDBM553828 | US10730826, Compound 74 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H24F4N2O3 |
|---|
| Mol. Mass. | 404.3991 |
|---|
| SMILES | NCCCC[C@@H](NC(=O)C1CCCC1)C(=O)COc1c(F)c(F)cc(F)c1F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
