| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl endopeptidase |
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| Ligand | BDBM554501 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Pharmacological Activity Assay |
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| IC50 | 0.510±n/a nM |
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| Citation |  Biber, N; Brockschnieder, D; Kölling, F; Meding, J; Miyatake Ondozabal, H; Neubauer, T; Schäfer, M; Zubov, D; Terjung, C Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors US Patent US11337973 Publication Date 5/24/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl endopeptidase |
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| Name: | Prolyl endopeptidase |
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| Synonyms: | PE | PEP | POP | PPCE_HUMAN | PREP | Post-proline cleaving enzyme | Prolyl oligopeptidase |
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| Type: | Enzyme |
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| Mol. Mass.: | 80688.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48147 |
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| Residue: | 710 |
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| Sequence: | MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI
LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
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| BDBM554501 |
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| n/a |
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| Name | BDBM554501 |
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| Synonyms: | US11337973, Example 5 | tert-Butyl (5RS)-5-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-fluoro-3-(trifluoromethyl)benzyl]-3-oxo-2,5,6,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-7(3H)-carboxylate (Diastereomer Mixture; 2 Isomers) |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26F5N5O4 |
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| Mol. Mass. | 531.4757 |
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| SMILES | CC(C)(C)OC(=O)N1CC(C(=O)N2CC[C@H](F)C2)n2c(C1)nn(Cc1ccc(F)c(c1)C(F)(F)F)c2=O |r| |
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| Structure | 
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