| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl endopeptidase |
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| Ligand | BDBM554507 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Pharmacological Activity Assay |
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| IC50 | 0.935±n/a nM |
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| Citation |  Biber, N; Brockschnieder, D; Kölling, F; Meding, J; Miyatake Ondozabal, H; Neubauer, T; Schäfer, M; Zubov, D; Terjung, C Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors US Patent US11337973 Publication Date 5/24/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl endopeptidase |
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| Name: | Prolyl endopeptidase |
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| Synonyms: | PE | PEP | POP | PPCE_HUMAN | PREP | Post-proline cleaving enzyme | Prolyl oligopeptidase |
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| Type: | Enzyme |
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| Mol. Mass.: | 80688.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48147 |
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| Residue: | 710 |
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| Sequence: | MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI
LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
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| BDBM554507 |
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| n/a |
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| Name | BDBM554507 |
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| Synonyms: | (5RS)-5-{[(3S)-3-Fluoropyrrolidin-1-yl]carbonyl}-7-methyl-2-(4-methylbenzyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3(2H)-one (Diastereomer Mixture; 2 Isomers) | US11337973, Example 11 | US11337973, Example 12 | US11337973, Example 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24FN5O2 |
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| Mol. Mass. | 373.4246 |
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| SMILES | CN1CC(C(=O)N2CC[C@H](F)C2)n2c(C1)nn(Cc1ccc(C)cc1)c2=O |r| |
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| Structure | 
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