Reaction Details |
| Report a problem with these data |
Target | Prolyl endopeptidase |
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Ligand | BDBM554524 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Pharmacological Activity Assay |
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IC50 | 2.20±n/a nM |
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Citation | Biber, N; Brockschnieder, D; Kölling, F; Meding, J; Miyatake Ondozabal, H; Neubauer, T; Schäfer, M; Zubov, D; Terjung, C Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors US Patent US11337973 Publication Date 5/24/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Prolyl endopeptidase |
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Name: | Prolyl endopeptidase |
Synonyms: | PE | PEP | POP | PPCE_HUMAN | PREP | Post-proline cleaving enzyme | Prolyl oligopeptidase |
Type: | Enzyme |
Mol. Mass.: | 80688.50 |
Organism: | Homo sapiens (Human) |
Description: | P48147 |
Residue: | 710 |
Sequence: | MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI
LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
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BDBM554524 |
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n/a |
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Name | BDBM554524 |
Synonyms: | (5RS)N-tert-Butyl-2-(4-methylbenzyl)-3-oxo-5-(pyrrolidin-1-ylcarbonyl)-2,5,6,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-7(3H)-carboxamide (Racemate) | US11337973, Example 28 |
Type | Small organic molecule |
Emp. Form. | C23H32N6O3 |
Mol. Mass. | 440.5386 |
SMILES | Cc1ccc(Cn2nc3CN(CC(C(=O)N4CCCC4)n3c2=O)C(=O)NC(C)(C)C)cc1 |
Structure |
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