| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl2-associated agonist of cell death |
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| Ligand | BDBM555338 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogeneous Time Resolved Fluorescence (HTRF) Assay |
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| IC50 | <10±n/a nM |
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| Citation |  Pinchman, JR; Huang, PQ; Bunker, KD; Sit, RK; Samatar, AA Benzamide compounds US Patent US11344546 Publication Date 5/31/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl2-associated agonist of cell death |
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| Name: | Bcl2-associated agonist of cell death |
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| Synonyms: | BAD | BAD_HUMAN | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-XL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-antagonist of cell death (BAD) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18393.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_478760 |
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| Residue: | 168 |
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| Sequence: | MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSH
HGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDE
FVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
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| BDBM555338 |
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| n/a |
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| Name | BDBM555338 |
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| Synonyms: | (R)-4-(4-((2-(3-(Difluoromethyl)bicyclo[1.1.1]pentan-1-yl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((4-((4-(4-(dimethylamino)piperidin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide | US11344546, Example 62 |
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| Type | Small organic molecule |
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| Emp. Form. | C50H65F5N6O5S3 |
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| Mol. Mass. | 1021.275 |
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| SMILES | CN(C)C1CCN(CC[C@H](CSc2ccccc2)Nc2ccc(cc2S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c2ccc(cc2)N2CCN(CC3=C(CC(C)(C)CC3)C34CC(C3)(C4)C(F)F)CC2)CC1 |r,t:52| |
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| Structure | 
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