| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bcl2-associated agonist of cell death |
|---|
| Ligand | BDBM552945 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Homogeneous Time Resolved Fluorescence (HTRF) Assay |
|---|
| IC50 | <10±n/a nM |
|---|
| Citation |  Pinchman, JR; Huang, PQ; Bunker, KD; Sit, RK; Samatar, AA Benzamide compounds US Patent US11344546 Publication Date 5/31/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bcl2-associated agonist of cell death |
|---|
| Name: | Bcl2-associated agonist of cell death |
|---|
| Synonyms: | BAD | BAD_HUMAN | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-XL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-antagonist of cell death (BAD) |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 18393.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_478760 |
|---|
| Residue: | 168 |
|---|
| Sequence: | MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSH
HGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDE
FVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
|
|
|
|---|
| BDBM552945 |
|---|
| n/a |
|---|
| Name | BDBM552945 |
|---|
| Synonyms: | (R)-4-(4-((6-(3-(difluoromethyl)bicyclo[1.1.1]pentan-1-yl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)-N-((4-((4-(4-hydroxypiperidin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide | US11318134, Example 67 | US11344546, Example 67 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C49H60F5N5O6S3 |
|---|
| Mol. Mass. | 1006.218 |
|---|
| SMILES | OC1CCN(CC[C@H](CSc2ccccc2)Nc2ccc(cc2S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c2ccc(cc2)N2CCN(CC3=C(CC4(CCC4)CC3)C34CC(C3)(C4)C(F)F)CC2)CC1 |t:50| |
|---|
| Structure | 
|
|---|
Search and Browse
