| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 26A1 |
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| Ligand | BDBM476225 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Retinoid Activity Assays |
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| IC50 | 3170±n/a nM |
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| Citation |  Cameron, DA; Petkovich, M; Rantanen, TK; Snieckus, V; Board, J; Singh, S; Maheta, AJ Compounds and methods for inhibiting CPY26 enzymes US Patent US11364220 Publication Date 6/21/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 26A1 |
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| Name: | Cytochrome P450 26A1 |
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| Synonyms: | CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 56216.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43174 |
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| Residue: | 497 |
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| Sequence: | MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI
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| BDBM476225 |
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| n/a |
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| Name | BDBM476225 |
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| Synonyms: | US10874634, Cmpd No. 08 | US11364220, Compound 08 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27NO3 |
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| Mol. Mass. | 365.4654 |
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| SMILES | CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(CC(O)=O)cc3)ccc12 |
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| Structure | 
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