Reaction Details | |||
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Target | Histone-lysine N-methyltransferase 2A/Menin | ||
Ligand | BDBM470586 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inbinition of the Menin-MLL Binding | ||
IC50 | 7.00±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase 2A/Menin | |||
Name: | Histone-lysine N-methyltransferase 2A/Menin | ||
Synonyms: | Menin-MLL Complex | Menin/Histone-lysine N-methyltransferase 2A | ||
Type: | Protein | ||
Mol. Mass.: | n/a | ||
Description: | n/a | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Histone-lysine N-methyltransferase 2A | ||
Synonyms: | ALL-1 | ALL1 | ALL1 | C-terminal cleavage product of 180 kDa | CXXC-type zinc finger protein 7 | CXXC7 | HRX | HTRX | Histone-lysine N-methyltransferase 2A | KMT2A | KMT2A_HUMAN | Lysine N-methyltransferase 2A | MLL | MLL cleavage product C180 | MLL cleavage product N320 | MLL1 | Myeloid/lymphoid or mixed-lineage leukemia | Myeloid/lymphoid or mixed-lineage leukemia (MLL) | Myeloid/lymphoid or mixed-lineage leukemia protein 1 | N-terminal cleavage product of 320 kDa | TRX1 | Trithorax-like protein | Zinc finger protein HRX | p180 | p320 | ||
Type: | Protein | ||
Mol. Mass.: | 431905.67 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q03164 | ||
Residue: | 3969 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Menin | ||
Synonyms: | MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2 | ||
Type: | Protein | ||
Mol. Mass.: | 68022.55 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O00255 | ||
Residue: | 610 | ||
Sequence: |
| ||
BDBM470586 | |||
n/a | |||
Name | BDBM470586 | ||
Synonyms: | US10815241, Example 11 | US11369605, Example 11 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H39FN6O3 | ||
Mol. Mass. | 550.6675 | ||
SMILES | CC(C)N(C(C)C)C(=O)c1cc(F)ccc1Oc1cncnc1N1CC2(CN(C2)C(=O)C2NC3CCC2CC3)C1 |(-9.34,-3.59,;-8,-4.36,;-6.67,-3.59,;-8,-5.9,;-9.34,-6.67,;-10.67,-5.9,;-9.34,-8.21,;-6.67,-6.67,;-5.33,-5.9,;-6.67,-8.21,;-8,-8.98,;-8,-10.52,;-9.34,-11.29,;-6.67,-11.29,;-5.33,-10.52,;-5.33,-8.98,;-4,-8.21,;-2.67,-8.98,;-2.67,-10.52,;-1.33,-11.29,;,-10.52,;,-8.98,;-1.33,-8.21,;-1.33,-6.67,;-.24,-5.58,;-1.33,-4.49,;-.24,-3.4,;-1.33,-2.31,;-2.42,-3.4,;-1.33,-.77,;-2.67,,;;,1.54,;1.33,2.31,;2.67,1.54,;2.67,,;1.33,-.77,;1.08,.26,;1.08,1.28,;-2.42,-5.58,)| | ||
Structure | ![]() |