| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 7 |
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| Ligand | BDBM558862 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ADP-Glo Kinase Activity Assay |
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| IC50 | 2000±n/a nM |
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| Citation |  Scheidt, KA; Schiltz, GE; Clutter, MR; Kwong, AJ 3-arylindazoles as selective MEK4 inhibitors US Patent US11370770 Publication Date 6/28/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 7 |
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| Name: | Mitogen-activated protein kinase 7 |
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| Synonyms: | BMK1 | Big MAP kinase 1 | ERK5 | Extracellular signal-regulated kinase 5 (ERK5) | MAPK7 | MK07_HUMAN | PRKM7 |
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| Type: | Protein |
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| Mol. Mass.: | 88377.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13164 |
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| Residue: | 816 |
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| Sequence: | MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIET
IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI
LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH
RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT
QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS
LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA
PPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP
SPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALK
AALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERER
KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPV
QPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATS
TSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKS
QVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLAD
WLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
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| BDBM558862 |
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| n/a |
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| Name | BDBM558862 |
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| Synonyms: | US11370770, Compound 6n |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9F3N2O2 |
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| Mol. Mass. | 306.2394 |
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| SMILES | OC(=O)c1ccc(cc1)-c1n[nH]c2ccc(cc12)C(F)(F)F |
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| Structure | 
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