Reaction Details | |||
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Target | Orexin receptor type 2 | ||
Ligand | BDBM559713 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | IP-One Assay | ||
IC50 | 0.30±n/a nM | ||
Citation | L., BS; Ping, C; James, CD; Jian, L; T., RM; Li, X; Dexi, Y; Shishi, L 3-AMINO PYRROLIDINE AND PIPERIDINE MACROCYCLIC OREXIN RECEPTOR AGONISTS WIPOWO2022109117 Publication Date 5/27/2022 | ||
More Info.: | Get all data from this article, Assay Method | ||
Orexin receptor type 2 | |||
Name: | Orexin receptor type 2 | ||
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R | ||
Type: | Protein | ||
Mol. Mass.: | 50710.53 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O43614 | ||
Residue: | 444 | ||
Sequence: |
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BDBM559713 | |||
n/a | |||
Name | BDBM559713 | ||
Synonyms: | WO2022109117, Example 58 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H30F3N3O7S | ||
Mol. Mass. | 537.55 | ||
SMILES | C[C@@H]1C[C@H](NS(C)(=O)=O)[C@@H]2COC3CCC(CC3)c3nc(OCCOC(=O)N12)ccc3OC(F)(F)F |wD:1.0,3.3,9.29,(-.46,-5.42,;-.09,-3.95,;-1.06,-2.78,;-.25,-1.49,;-.81,-.07,;-2.32,.15,;-3.83,.36,;-2.54,-1.36,;-2.1,1.65,;1.23,-1.86,;1.71,-.36,;2.75,.88,;4.37,1.21,;5.71,2.05,;7.14,1.46,;7.35,-.1,;6.05,-.94,;4.67,-.3,;8.46,-1.29,;7.72,-2.65,;8.45,-4.02,;7.57,-5.29,;6.27,-6.12,;4.72,-6.29,;3.24,-5.84,;2.04,-4.82,;.84,-5.76,;1.33,-3.38,;10.01,-4.06,;10.74,-2.73,;10.03,-1.38,;10.85,-.1,;10.15,1.25,;8.63,1.32,;10.98,2.53,;11.67,1.18,)| | ||
Structure |