| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [L858R,T790M,C797S] |
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| Ligand | BDBM561456 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TBD |
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| IC50 | 0.210±n/a nM |
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| Citation |  Wu, L; Liu, X; Ding, CZ; Chen, S; Hu, L; Zhao, L; Pan, W; Hu, G; Li, J; Zhao, N; Zhao, J Aryl-phosphorus-oxygen compound as EGFR kinase inhibitor US Patent US11390625 Publication Date 7/19/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [L858R,T790M,C797S] |
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| Name: | Epidermal growth factor receptor [L858R,T790M,C797S] |
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| Synonyms: | EGFR | EGFR (L858R, T790M, C797S) | EGFR_HUMAN | ERBB | ERBB1 | HER1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 134337.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[L858R,T790M,C797S] |
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| Residue: | 1210 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
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| BDBM561456 |
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| n/a |
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| Name | BDBM561456 |
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| Synonyms: | US11390625, Compound 44 | US11390625, Example 44 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H36BrN8O2P |
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| Mol. Mass. | 639.526 |
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| SMILES | COc1cc(N2CCC(CC2)N(C)C)c(C)cc1Nc1ncc(Br)c(Nc2ccc3nccnc3c2P(C)(C)=O)n1 |
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| Structure | 
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