| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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| Ligand | BDBM565098 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | UCHL1 Biochemical IC50 Assay |
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| IC50 | 55000±n/a nM |
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| Citation |  Stockley, ML; Kemp, MI; Madin, A; Woodrow, MD Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors US Patent US11414402 Publication Date 8/16/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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| Synonyms: | Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 24819.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_974327 |
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| Residue: | 223 |
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| Sequence: | MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE
NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE
TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP
FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
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| BDBM565098 |
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| n/a |
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| Name | BDBM565098 |
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| Synonyms: | N-(1-cyanopyrrolidin-3- yl)-5-phenylpyridine-2- sulfonamide | US11414402, Example 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N4O2S |
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| Mol. Mass. | 328.389 |
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| SMILES | O=S(=O)(NC1CCN(C1)C#N)c1ccc(cn1)-c1ccccc1 |
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| Structure | 
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