| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metallo-beta-lactamase type 2 |
|---|
| Ligand | BDBM574740 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | metallo-beta-lactamase inhibition assay |
|---|
| IC50 | 834±n/a nM |
|---|
| Citation |  Cooper, I; Orr, D; Wilkinson, A; Finlayson, J; Bunt, A; Appelqvist, P; Wallberg, H; Wångsell, F Antibacterial compounds US Patent US11459296 Publication Date 10/4/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metallo-beta-lactamase type 2 |
|---|
| Name: | Metallo-beta-lactamase type 2 |
|---|
| Synonyms: | B2 metallo-beta-lactamase | BLAN1_KLEPN | Beta-lactamase NDM-1 | Beta-lactamase type II | Metallo-beta-lactamase NDM-1 | Metallo-beta-lactamase type 2 | Metallo-beta-lactamase type II | NDM-1 | New Delhi metallo-beta-lactamase-1 | blaNDM-1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 28498.15 |
|---|
| Organism: | Klebsiella pneumoniae |
|---|
| Description: | ChEMBL_103887 |
|---|
| Residue: | 270 |
|---|
| Sequence: | MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQ
HTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTH
AHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPL
KVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAF
PKASMIVMSHSAPDSRAAITHTARMADKLR
|
|
|
|---|
| BDBM574740 |
|---|
| n/a |
|---|
| Name | BDBM574740 |
|---|
| Synonyms: | 3-[1-(3-Aminopropanoyl)-4- piperidyl]-1-sulfamoyl-pyrrole- 2-carboxylic acid | US11459296, Example 63 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H20N4O5S |
|---|
| Mol. Mass. | 344.387 |
|---|
| SMILES | NCCC(=O)N1CCC(CC1)c1ccn(c1C(O)=O)S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
