| Reaction Details |
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 | Report a problem with these data |
| Target | PAS domain-containing serine/threonine-protein kinase [879-1323] |
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| Ligand | BDBM463470 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PASK ATP Radiochemical Assay |
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| IC50 | <10000±n/a nM |
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| Citation |  McCall, JM; Romero, DL; McKearn, J; Clare, M Heterocyclic compounds for the inhibition of PASK US Patent US11459307 Publication Date 10/4/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| PAS domain-containing serine/threonine-protein kinase [879-1323] |
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| Name: | PAS domain-containing serine/threonine-protein kinase [879-1323] |
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| Synonyms: | KIAA0135 | PAS domain-containing serine/threonine-protein kinase (PASK) (879-1323) | PASK | PASK_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49711.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 879-1323 |
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| Residue: | 445 |
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| Sequence: | MRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRD
SAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQK
YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR
VEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGY
LRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNP
YRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPER
RTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELC
GGPVPGEAPNGQGCLHPGDPRLLTS
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| BDBM463470 |
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| n/a |
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| Name | BDBM463470 |
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| Synonyms: | 2-Phenyl-3-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)quinoxaline-6-carboxylic acid | US10781185, Example 7 | US11459307, Example 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22F3N3O2 |
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| Mol. Mass. | 477.4777 |
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| SMILES | OC(=O)c1ccc2nc(-c3ccccc3)c(nc2c1)N1CCC(CC1)c1ccc(cc1)C(F)(F)F |
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| Structure | 
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