| Reaction Details |
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 | Report a problem with these data |
| Target | Programmed cell death 1 ligand/protein 1 |
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| Ligand | BDBM575483 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PD1-PDL1 HTRF Binding Activity Test |
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| IC50 | 0.180±n/a nM |
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| Citation |  Yang, F; Zhang, Y; Ying, H; Yu, H; Chen, Z; Xu, Y Biaryl derivative, preparation method thereof and pharmaceutical application thereof US Patent US11459339 Publication Date 10/4/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Programmed cell death 1 ligand/protein 1 |
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| Name: | Programmed cell death 1 ligand/protein 1 |
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| Synonyms: | PD-1/PD-L1 | Programmed cell death protein 1/Programmed cell death 1 ligand 1 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Programmed cell death protein 1 |
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| Synonyms: | CD_antigen=CD279 | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 | Protein PD-1 | hPD-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31650.07 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_108437 |
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| Residue: | 288 |
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| Sequence: | MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTS
ESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGT
YLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGS
LVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVP
CVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
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| Component 2 |
| Name: | Programmed cell death 1 ligand 1 |
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| Synonyms: | B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33278.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109807 |
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| Residue: | 290 |
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| Sequence: | MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
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| BDBM575483 |
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| n/a |
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| Name | BDBM575483 |
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| Synonyms: | US11459339, Example 2 | US11459339, Example 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H44N6O10 |
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| Mol. Mass. | 744.7902 |
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| SMILES | COC(=O)[C@@H](CO)NCc1cnc(cc1OC)C(=O)Nc1cccc(c1C)-c1cccc(NC(=O)c2cc(OC)c(CN[C@H](CO)C(=O)OC)cn2)c1C |r| |
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| Structure | 
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