Reaction Details |
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Target | Programmed cell death 1 ligand/protein 1 |
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Ligand | BDBM575621 |
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Substrate/Competitor | n/a |
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Meas. Tech. | PD1-PDL1 HTRF Binding Activity Test |
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IC50 | 0.330±n/a nM |
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Citation | Yang, F; Zhang, Y; Ying, H; Yu, H; Chen, Z; Xu, Y Biaryl derivative, preparation method thereof and pharmaceutical application thereof US Patent US11459339 Publication Date 10/4/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Programmed cell death 1 ligand/protein 1 |
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Name: | Programmed cell death 1 ligand/protein 1 |
Synonyms: | PD-1/PD-L1 | Programmed cell death protein 1/Programmed cell death 1 ligand 1 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Programmed cell death protein 1 |
Synonyms: | CD_antigen=CD279 | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 | Protein PD-1 | hPD-1 |
Type: | PROTEIN |
Mol. Mass.: | 31650.07 |
Organism: | Homo sapiens |
Description: | ChEMBL_108437 |
Residue: | 288 |
Sequence: | MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTS
ESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGT
YLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGS
LVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVP
CVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
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Component 2 |
Name: | Programmed cell death 1 ligand 1 |
Synonyms: | B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1 |
Type: | PROTEIN |
Mol. Mass.: | 33278.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109807 |
Residue: | 290 |
Sequence: | MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
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BDBM575621 |
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n/a |
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Name | BDBM575621 |
Synonyms: | (2R,2′R)-2,2′-((((((2,2′-dimethyl-[1,1′- biphenyl]-3,3′-diyl)bis(azanediyl))bis (carbonyl))bis(4-methoxypyridine-6,3- diyl))bis(methylene))bis(azanediyl)bis(4- hydroxybutanoic acid) | US11459339, Example 71 |
Type | Small organic molecule |
Emp. Form. | C38H44N6O10 |
Mol. Mass. | 744.7902 |
SMILES | COc1cc(ncc1CN[C@H](CCO)C(O)=O)C(=O)Nc1cccc(c1C)-c1cccc(NC(=O)c2cc(OC)c(CN[C@H](CCO)C(O)=O)cn2)c1C |r| |
Structure |
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