Ki Summary

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Target

cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712]

Ligand

BDBM577162

Substrate/Competitor

n/a

IC50

16.7±n/a nM

Citation

Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent US11472805 Publication Date 10/18/2022

More Info.:

Get all data from this article, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712]

Name:

cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712]

Synonyms:

DPDE1 | PDE4C | PDE4C_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C1)(2-712)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

79744.34

Organism:

n/a

Description:

aa 2-712

Residue:

711

Sequence:

ENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDL
SPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFL
YRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAA
KQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRIL
NRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSAS
LSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLK
TFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAA
LFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLS
AKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNL
VHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFI
DYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELT
LEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT

BDBM577162

n/a

Name

BDBM577162

Synonyms:

8-Cyclopropyl-10-(2,4-dimethyl-phenyl)pyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-9(8H)-one | US11472805, Example 66

Type

Small organic molecule

Emp. Form.

C21H19N3O

Mol. Mass.

329.3951

SMILES

Cc1ccc(-c2c3ncccc3n3ccn(C4CC4)c(=O)c23)c(C)c1 |(.96,4.96,;.48,3.49,;1.51,2.35,;1.04,.89,;-.47,.57,;-.94,-.9,;-2.41,-1.38,;-3.74,-.61,;-5.08,-1.38,;-5.08,-2.92,;-3.74,-3.69,;-2.41,-2.92,;-.94,-3.39,;-.32,-4.8,;1.21,-4.96,;2.12,-3.71,;3.65,-3.87,;4.87,-4.82,;5.08,-3.29,;1.49,-2.31,;2.4,-1.06,;-.04,-2.15,;-1.5,1.71,;-3,1.39,;-1.02,3.17,)|

Structure