Reaction Details |
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Target | Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E] |
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Ligand | BDBM581058 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Homogenous Time-Resolved Fluorescence (HTRF) Binding Assays |
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IC50 | 4.00±n/a nM |
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Citation | Miller, II, MM; Allen, MP; Li, L Cyclic peptide immunomodulators US Patent US11492375 Publication Date 11/8/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E] |
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Name: | Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E] |
Synonyms: | PD-1/PD-L |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S] |
Synonyms: | Complex of Programmed cell death protein 1 [25-167,N33K] and Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S] | hPD1(25-167)-3S-IG |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 42672.97 |
Organism: | Homo sapiens (Human) |
Description: | Q15116[25-167,N33K],P01857[99-330,C104S,C109S,C112S,L118I,P121S] |
Residue: | 384 |
Sequence: | LDSPDRPWKPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPE
DRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRV
TERRAEVPTAHPSPSPRPAGQFQGSPGGGGGREPKSSDKTHTSPPSPAPELIGGSSVFLF
PPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVV
SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQV
SLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVF
SCSVMHEALHNHYTQKSLSLSPGK
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Component 2 |
Name: | Programmed cell death 1 ligand 1 [18-239,H172E] |
Synonyms: | B7H1 | CD274 | PD1L1_HUMAN | PDCD1L1 | PDCD1LG1 | PDL1 | hPDL1(18-239)-TVMV-His |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 27269.94 |
Organism: | Homo sapiens (Human) |
Description: | Q9NZQ7[18-239,H172E] |
Residue: | 238 |
Sequence: | AFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQ
HSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKI
NQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDEQVLSGKTTTTNSKREEKLFNVTSTL
RINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTGSEETVRFQGHHHHHH
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BDBM581058 |
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n/a |
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Name | BDBM581058 |
Synonyms: | US11492375, Example 1120 |
Type | Small organic molecule |
Emp. Form. | C91H119N21O22S |
Mol. Mass. | 1891.111 |
SMILES | C[C@@H]1NC(=O)[C@@H]2CCCC\C=C/CCCC[C@H](N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCCN3C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)CSC[C@H](NC1=O)C(=O)NCC(N)=O)C(=O)N2C |r,c:10| |
Structure |
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