| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma [238-497] |
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| Ligand | BDBM175845 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET Assay |
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| pH | 6.8±n/a |
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| IC50 | 500±n/a nM |
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| Comments | extracted |
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| Citation |  Finsinger, D; Wucherer-Plietker, M; Blume, B Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors US Patent US9688684 Publication Date 6/27/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma [238-497] |
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| Name: | Nuclear receptor ROR-gamma [238-497] |
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| Synonyms: | NR1F3 | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor gamma (RORgamma-LBD) |
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| Type: | Protein |
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| Mol. Mass.: | 29835.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human RORgamma ligand-binding domain. |
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| Residue: | 260 |
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| Sequence: | HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRS
NIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGA
MEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEI
ALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCS
QHVERLQIFQHLHPIVVQAA
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| BDBM175845 |
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| n/a |
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| Name | BDBM175845 |
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| Synonyms: | US9688684, Compound 42: 8-(4-Chloro-phenyl)-7-(3-fluoro-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15ClFN5 |
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| Mol. Mass. | 343.786 |
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| SMILES | Fc1cccc(CN2CCn3nnnc3C2c2ccc(Cl)cc2)c1 |
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| Structure | 
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