| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma [238-497] |
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| Ligand | BDBM175864 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET Assay |
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| pH | 6.8±n/a |
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| IC50 | 500±n/a nM |
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| Comments | extracted |
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| Citation |  Finsinger, D; Wucherer-Plietker, M; Blume, B Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors US Patent US9688684 Publication Date 6/27/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma [238-497] |
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| Name: | Nuclear receptor ROR-gamma [238-497] |
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| Synonyms: | NR1F3 | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor gamma (RORgamma-LBD) |
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| Type: | Protein |
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| Mol. Mass.: | 29835.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human RORgamma ligand-binding domain. |
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| Residue: | 260 |
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| Sequence: | HPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRS
NIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGA
MEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEI
ALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCS
QHVERLQIFQHLHPIVVQAA
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| BDBM175864 |
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| n/a |
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| Name | BDBM175864 |
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| Synonyms: | US9688684, Compound 61: 8-(3-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N7S |
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| Mol. Mass. | 405.519 |
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| SMILES | CC(C)c1nn(cc1C1N(Cc2cccs2)CCn2nnnc12)-c1ccccc1 |
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| Structure | 
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