Reaction Details |
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Target | Aromatase |
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Ligand | BDBM8879 |
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Substrate/Competitor | BDBM8885 |
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Meas. Tech. | CYP11B Assay |
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IC50 | 20±n/a nM |
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Citation | Ulmschneider, S; Muller-Vieira, U; Mitrenga, M; Hartmann, RW; Oberwinkler-Marchais, S; Klein, CD; Bureik, M; Bernhardt, R; Antes, I; Lengauer, T Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem48:1796-805 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Aromatase |
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Name: | Aromatase |
Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
Type: | Enzyme |
Mol. Mass.: | 57888.92 |
Organism: | Homo sapiens (Human) |
Description: | P11511 |
Residue: | 503 |
Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
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BDBM8879 |
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BDBM8885 |
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Name | BDBM8879 |
Synonyms: | 5-[(E)-(5-Fluoro-2,3-dihydro-1H-inden-1-ylidene)methyl]-1H-imidazole | 5-{[(1E)-5-fluoro-2,3-dihydro-1H-inden-1-ylidene]methyl}-1H-imidazole | Imidazolylmethyleneindane 7a | Imidazolylmethyleneindane 7b |
Type | Small organic molecule |
Emp. Form. | C13H11FN2 |
Mol. Mass. | 214.2382 |
SMILES | Fc1ccc2C(CCc2c1)=Cc1cnc[nH]1 |w:10.12| |
Structure |
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