| Reaction Details |
|---|
 | Report a problem with these data |
| Target | TRAF2 and NCK-interacting protein kinase |
|---|
| Ligand | BDBM585239 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TNIK Human STE Kinase Enzymatic Radiometric Assay |
|---|
| IC50 | 6.5±n/a nM |
|---|
| Citation |  Zavoronkovs, A; Aliper, A; Aladinskiy, V; Kukharenko, A Analogs for the treatment of disease US Patent US11530197 Publication Date 12/20/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| TRAF2 and NCK-interacting protein kinase |
|---|
| Name: | TRAF2 and NCK-interacting protein kinase |
|---|
| Synonyms: | KIAA0551 | TNIK | TNIK_HUMAN | TRAF2 and NCK-interacting protein kinase (TNIK) | TRAF2- and NCK-interacting kinase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 154954.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UKE5 |
|---|
| Residue: | 1360 |
|---|
| Sequence: | MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
|
|
|
|---|
| BDBM585239 |
|---|
| n/a |
|---|
| Name | BDBM585239 |
|---|
| Synonyms: | US11530197, Compound 175 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H24F3N7O |
|---|
| Mol. Mass. | 495.4996 |
|---|
| SMILES | CN1CCN(CC1)c1ccc(NC(=O)c2c[nH]c(n2)-c2ncn(C(F)F)c2-c2ccc(F)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
