Reaction Details | |||
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Target | TRAF2 and NCK-interacting protein kinase | ||
Ligand | BDBM585247 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | TNIK Human STE Kinase Enzymatic Radiometric Assay | ||
IC50 | 6.5±n/a nM | ||
Citation | Zavoronkovs, A; Aliper, A; Aladinskiy, V; Kukharenko, A Analogs for the treatment of disease US Patent US11530199 Publication Date 12/20/2022 | ||
More Info.: | Get all data from this article, Assay Method | ||
TRAF2 and NCK-interacting protein kinase | |||
Name: | TRAF2 and NCK-interacting protein kinase | ||
Synonyms: | KIAA0551 | TNIK | TNIK_HUMAN | TRAF2 and NCK-interacting protein kinase (TNIK) | TRAF2- and NCK-interacting kinase | ||
Type: | Protein | ||
Mol. Mass.: | 154954.98 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9UKE5 | ||
Residue: | 1360 | ||
Sequence: |
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BDBM585247 | |||
n/a | |||
Name | BDBM585247 | ||
Synonyms: | US11530197, Compound 158 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H36FN7O3 | ||
Mol. Mass. | 573.661 | ||
SMILES | OCCN1CCN(CC1)c1ccc(NC(=O)c2c[nH]c(n2)-c2c(ncn2C2CC[C@H](O)CC2)-c2ccc(F)cc2)cc1 |r,wD:29.32,(-11.47,1.09,;-9.93,1.09,;-9.16,-.25,;-7.62,-.25,;-6.85,-1.58,;-5.31,-1.58,;-4.54,-.25,;-5.31,1.09,;-6.85,1.09,;-3,-.25,;-2.23,-1.58,;-.69,-1.58,;.08,-.25,;1.62,-.25,;2.39,1.09,;1.62,2.42,;3.93,1.09,;4.84,2.33,;6.3,1.86,;6.3,.32,;4.84,-.16,;7.55,-.59,;9.01,-.11,;9.92,-1.36,;9.01,-2.6,;7.55,-2.13,;6.3,-3.03,;6.46,-4.56,;5.22,-5.47,;3.81,-4.84,;2.56,-5.75,;3.65,-3.31,;4.89,-2.41,;9.49,1.35,;10.99,1.67,;11.47,3.14,;10.44,4.28,;10.91,5.75,;8.93,3.96,;8.46,2.5,;-.69,1.09,;-2.23,1.09,)| | ||
Structure |