Reaction Details |
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Target | GTPase KRas [G12D,Q61H] |
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Ligand | BDBM485654 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Ras GTP Binding Domain Inhibition Assay |
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IC50 | <5000±n/a nM |
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Citation | Hadari, YR; Carta, L; Schmertzler, M; Williams, TM; Reynolds, CH; Hutcheson, R Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease US Patent US11541041 Publication Date 1/3/2023 |
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More Info.: | Get all data from this article, Assay Method |
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GTPase KRas [G12D,Q61H] |
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Name: | GTPase KRas [G12D,Q61H] |
Synonyms: | GTPase KRas (G12D, Q61H) | KRAS | KRAS2 | RASK2 | RASK_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 21722.64 |
Organism: | Homo sapiens (Human) |
Description: | P01116[G12D,Q61H] |
Residue: | 189 |
Sequence: | MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
HEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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BDBM485654 |
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n/a |
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Name | BDBM485654 |
Synonyms: | US10940139, Example 02511 | US11000515, Compound TABLE 7.62 | US11213515, TABLE 7.62 | US11541041, Compound Table 7.41 |
Type | Small organic molecule |
Emp. Form. | C17H14N6O2 |
Mol. Mass. | 334.3321 |
SMILES | CC(Oc1cccc(c1)C#N)C(=O)Nc1nnc([nH]1)-c1ccccn1 |
Structure |
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