| Reaction Details |
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 | Report a problem with these data |
| Target | Hsp90 co-chaperone Cdc37 |
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| Ligand | BDBM279676 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Hsp90 chaperone assay |
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| IC50 | 5500±n/a nM |
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| Citation |  Cai, X; Qian, C; Zhai, H Fused amino pyridine as HSP90 inhibitors US Patent US11560377 Publication Date 1/24/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Hsp90 co-chaperone Cdc37 |
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| Name: | Hsp90 co-chaperone Cdc37 |
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| Synonyms: | CDC37 | CDC37A | CDC37_HUMAN | Hsp90 co-chaperone |
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| Type: | Molecular Chaperone |
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| Mol. Mass.: | 44453.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16543 |
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| Residue: | 378 |
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| Sequence: | MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRK
VAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLS
KDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVH
LVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTK
IKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYES
LPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPG
DPLLEAVPKTGDEKDVSV
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| BDBM279676 |
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| n/a |
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| Name | BDBM279676 |
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| Synonyms: | US10035797, Compound 14 | US10428068, Compound 14 | US10844056, Compound 14 | US11560377, Compound 14 | US9630965, Compound 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17ClN4OS |
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| Mol. Mass. | 372.872 |
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| SMILES | COc1ccc(Cl)c(Sc2nc3c(N)nccc3n2CCCC#C)c1 |
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| Structure | 
|
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