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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Ubiquitin carboxyl-terminal hydrolase 14 | ||
| Ligand | BDBM590272 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Usp14 Inhibition Assay | ||
| IC50 | <50±n/a nM | ||
| Citation |  Cullen, M; Bastos, CM; Parks, D; Munoz, B Proteasome activity enhancing compounds US Patent US11560385 Publication Date 1/24/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Ubiquitin carboxyl-terminal hydrolase 14 | |||
| Name: | Ubiquitin carboxyl-terminal hydrolase 14 | ||
| Synonyms: | Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 56058.38 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_103728 | ||
| Residue: | 494 | ||
| Sequence: |
| ||
| BDBM590272 | |||
| n/a | |||
| Name | BDBM590272 | ||
| Synonyms: | US11560385, Compound 45B | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H28N4O2 | ||
| Mol. Mass. | 428.5261 | ||
| SMILES | Cc1c(cc(C[C@H]2C[C@@H](C2)C#N)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,wU:8.10,wD:6.5,29.33,TLB:23:24:29.31:27.26,THB:30:29:27.26:24,(-3.57,-.98,;-2.24,-.21,;-1.76,1.25,;-.22,1.25,;.25,-.21,;1.74,-.61,;2.83,.48,;4.37,.48,;4.37,2.02,;2.83,2.02,;5.46,3.1,;6.55,4.19,;-.99,-1.12,;-.99,-2.66,;-2.33,-3.43,;-2.33,-4.97,;-.99,-5.74,;.34,-4.97,;.34,-3.43,;-.99,-7.28,;-.99,-8.82,;-2.85,2.34,;-4.34,1.94,;-2.45,3.83,;-3.54,4.92,;-4.64,6,;-3.3,6.77,;-2.9,8.26,;-4.24,7.49,;-5.78,7.49,;-6.55,8.82,;-6.18,6,)| | ||
| Structure | 
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