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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Ubiquitin carboxyl-terminal hydrolase 14 | ||
| Ligand | BDBM590691 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Usp14 Inhibition Assay | ||
| IC50 | <50±n/a nM | ||
| Citation |  Cullen, M; Bastos, CM; Parks, D; Munoz, B Proteasome activity enhancing compounds US Patent US11560385 Publication Date 1/24/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Ubiquitin carboxyl-terminal hydrolase 14 | |||
| Name: | Ubiquitin carboxyl-terminal hydrolase 14 | ||
| Synonyms: | Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 56058.38 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_103728 | ||
| Residue: | 494 | ||
| Sequence: |
| ||
| BDBM590691 | |||
| n/a | |||
| Name | BDBM590691 | ||
| Synonyms: | US11560385, Compound 132B | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H26FN3O2 | ||
| Mol. Mass. | 407.4805 | ||
| SMILES | Cc1c(cc(C2CC(F)C2)n1-c1ccc(cc1)C#N)C(=O)CN1C2CCC1[C@@H](O)C2 |r,wD:27.31,TLB:21:22:27.29:25.24,THB:28:27:25.24:22,(-2.97,-.98,;-1.63,-.21,;-1.16,1.25,;.38,1.25,;.86,-.21,;2.35,-.61,;3.12,-1.95,;4.45,-1.18,;5.94,-1.58,;3.68,.16,;-.39,-1.12,;-.39,-2.66,;-1.72,-3.43,;-1.72,-4.97,;-.39,-5.74,;.95,-4.97,;.95,-3.43,;-.39,-7.28,;-.39,-8.82,;-2.24,2.34,;-3.73,1.94,;-1.85,3.83,;-2.93,4.92,;-4.03,6,;-2.7,6.77,;-2.3,8.26,;-3.63,7.49,;-5.17,7.49,;-5.94,8.82,;-5.57,6,)| | ||
| Structure | 
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