Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM590736 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibitory Activity Assay |
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IC50 | 0.340±n/a nM |
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Citation | Kamioka, S; Ban, H; Matsuoka, M; Hirose, W; Shimada, N; Hayashi, K; Umehara, H 5-heteroaryl-1H-pyrazol-3-amine derivative US Patent US11564920 Publication Date 1/31/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM590736 |
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n/a |
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Name | BDBM590736 |
Synonyms: | US11564920, Example 20 |
Type | Small organic molecule |
Emp. Form. | C19H19FN8O2 |
Mol. Mass. | 410.405 |
SMILES | COc1cncc(OC[C@]2(F)CCNC2)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1 |r| |
Structure |
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